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Other classes of drugs in development include lipase inhibitors, similar to orlistat. Another lipase inhibitor, called GT 389-255, was being developed by Peptimmune (licensed from Genzyme). This was a novel combination of an inhibitor and a polymer designed to bind the undigested triglycerides therefore allowing increased fat expulsion without side effects such as oily stools that occur with orlistat. The development stalled as Phase 1 trials were conducted in 2004 and there was no further human clinical development afterward. In 2011, Peptimmune filed for Chapter 7 Liquidation.
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If you have serious health problems because of your weight — and lifestyle changes haven’t resulted in significant weight loss — prescription weight-loss drugs may be an option. You should know, though, that prescription weight-loss drugs don’t replace the need to make healthy changes in your eating habits and activity level.
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Jump up ^ Grunfeld C, Kotler D, Dobs A, Glesby M, Bhasin S (2006). “Oxandrolone in the treatment of HIV-associated weight loss in men: a randomized, double-blind, placebo-controlled study”. J Acquir Immune Defic Syndr. 41 (3): 304–14. doi:10.1097/01.qai.0000197546.56131.40. PMID 16540931.
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Tests for heart valve damage were done on 3,270 participants, but no significant differences in rates were identified.
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